He became popular as Dr. Derek Shepherd, or "McDreamy," on Grey's Anatomy and was nominated for a MTV Movie Award for Best Kiss for his role as Robert in 2007's Enchanted. In 2011, he played the character Dylan in the blockbuster film Transformers: Dark of the Moon.
He played roles in the 2002 film Sweet Home Alabama and the 2008 film Made of Honor.
He co-starred with Ellen Pompeo on Grey's Anatomy.
He was diagnosed with Dyslexia at age 12, so he had to memorize all his lines for auditions and during high school he tied for second in a national juggling championship.
He married Jillian Fink in 1999, and they had a daughter named Talula in 2002 and twins named Sullivan Patrick and Darby Galen in 2007. In early 2015, Fink filed for divorce.
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