He was in Dark Knight and later had the lead role in Dolphin Tale. In television, he has appeared on CSI, House M.D., and Without a Trace.
He has been nominated for several Young Artist Awards.
He was in the 2008 film, Marley & Me, which starred Jennifer Aniston.
He had his first film acting experience in the movie Babel, which starred Brad Pitt. After this, he had an uncredited role in the 2007 film, Deeply Irresponsible.
His mother, Christie Gamble, was a theater actress. She and Nathan's father ran a drama camp and worked as theater directors.