He became known for his portrayal of the logical Mr. Spock on the 1966-1969 Star Trek series, during which he received three Emmy Award nominations.
He made a Cameo appearance in the 2013 film Star Trek Into Darkness and provided the voice of King Kashekim Nedakh in Atlantis: The Lost Empire.
He co-starred alongside William Shatner in the original Star Trek, and in an episode of The Man from U.N.C.L.E.
He began acting at age eight in local theater productions, despite his parents' initial reservations.
His father ran a barbershop in Boston, where he specialized in the popular Spock Cut. He married Sandra Zober in 1954, and together they had a son named Adam and a daughter named Julie.