Born Scott Ramon Seguro Mescudi, his song, "Day 'n' Nite", became a top five Billboard hit, and his 2009 album, Man on the Moon: The End of Day, went certified Gold. He appeared in the 2014 film Need for Speed and in an episode of the fox comedy Brooklyn Nine-Nine.
His second studio album, Man on the Moon II: The Legend of Mr. Rager, reached the top 5 position on the US charts.
He co-starred with Bryan Greenberg in the HBO series, How to Make It in America.
He had three older siblings, and endured childhood trauma at age 11 when his father died of cancer.
He dated model and environmentalist Jamie Baratta from 2009 to 2012; his first daughter, Vada Mescudi, was born in 2010.