After appearing as Beverly in seventeen episodes of the CBS soap opera The Bold and the Beautiful, Rodriguez starred in the 2012 musical movie Filly Brown. In 2014, she was cast in the starring role in The CW series Jane the Virgin. The role earned her a 2015 Golden Globe Award for Best Actress in a TV Series, Musical or Comedy.
She worked and trained at the Atlantic Theatre Company.
One of Rodriguez's Filly Brown co-stars, Jenni Rivera, died tragically in a plane crash shortly after the film was released.
After training as a salsa dancer during her childhood years, she studied theater at New York University's famous Tisch School of the Arts.
She and her two older sisters grew up in a Puerto Rican family in Chicago, Illinois.