Has had recurring roles on the television series, ER, Now and Again, and Melrose Place, but received his most praise as a supporting actor in Life Goes On.
His then wife, Hillary Swank forgot to thank him when she accepted her Academy Award in 2000.
His older brother is actor, Rob Lowe.
He attended Santa Monica High School with many celebrities including Robert Downey Jr. and Charlie Sheen.
He married Hilary Swank in 1997, and the couple divorced in 2007.
- The meaning of the name Lowe: Little Wolf